PepX: a structural database of protein-peptide complexes

The PepX Database contains over 500 unique protein-peptide interface clusters, representing the full diversity of structural information on protein-peptide complexes available in the PDB (hence PepX = Peptide CompleXes). The unbiased approach used for clustering the complexes, using only geometrical parameters and no functional or sequence information, ensures that the resulting clusters represent a structurally non-redundant set, and thus provide a strong basis for docking and design experiments. Thorough annotation of each complex with both biological and structural information facilitates searching for and browsing through individual complexes and clusters.

Read how we constructed PepX.

PepX was developed by

• Peter Vanhee, Switch Laboratory
• Prof. Dr. Joost Schymkowitz, Switch Laboratory
• Prof. Dr. Frederic Rousseau, Switch Laboratory
• Prof. Dr. Luis Serrano, Centre de Regulació Genòmica
• Dr. Francois Stricher, Centre de Regulació Genòmica

Website by

• Peter Vanhee, Switch Laboratory
• Dr. Joke Reumers, Switch Laboratory

With contributions of

• Dr. Joke Reumers, Switch Laboratory
• Lies Baeten, Switch Laboratory
• Dr. Cedric Magis, Centre de Regulació Genòmica

References

• Vanhee, P., J. Reumers, et al. (2009). "PepX: A structural database of non-redundant protein-peptide complexes" NAR October 2009.
• Vanhee, P., F. Stricher, et al. (2009). "Protein-peptide interactions adopt the same structural motifs as monomeric protein folds." Structure August 2009