27647 3EQS 11.4958 14.3463 -1.93 B=6 C=11 H=56 T=28 C=27 H=55 T=18 Crystal structure of human MDM2 in complex with a 12-mer peptide inhibitor -21.11 B 11 A 56 55 -2.12 Q00987 E3 ubiquitin-protein ligase Mdm2 MDM2_HUMAN MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP 27647 2Z5T 19.4691 27.8701 -1.53 2z5tM00 B=5 C=23 E=5 H=55 T=14 C=36 H=55 T=9 Molecular basis for the inhibition of p53 by Mdmx -18.59 P 11 MO 60 55 -1.42 Q7ZUW7 Protein Mdm4 MDM4_DANRE MTSLASSSQLPGSCRTLPGEGTQVHPRAPLLQILKVAGAQEEVFTLKEVMHYLGQYIMMKQLYDKQRQHIVHCHDDPLGELLEVGSFSVKNPSPVYEMLKRNLVILNNSDAAKNLSVGKDSNESPSEDPGQVSSGSINSAQPLIAGSSSTGTTQSCSQRRPRDPDEDSSDGLPRSACKRPKLDVTLEEWDLSGLPWWFLGNLRSNYTRRSNGSTDIHTNQLSPGQDEDTAIVSDTTDDLWFLNEAESEQVSVEIKEAVLEQGSDGESPHEDEDTGKDSKDDGKMQEEQEEDSQCLSDDTDTEISTQDAWQCSECRKFNTPLQRYCMRCWALRKDWYKDCPRLVHSISVPDIPACSSRPERDEDEEEEDDDGIDMPDCLRTVSDPVVLPSHRVSRNIPSSSASSSKGKGPSQIHHHFQETSEGDSQDTLDMETEYQPEALLEPCKLCRVRPRNGNIIHGRTAHLITCFPCARKLHKFHAPCPGCGQVIQKVIKTFIA 27647 3EQY 20.396 25.0005 -1.58 C=22 E=13 H=57 T=9 C=42 H=50 T=8 Crystal structure of human MDMX in complex with a 12-mer peptide inhibitor -22.57 C 12 A 70 50 -2.26 O15151 Protein Mdm4 MDM4_HUMAN MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA 27647 1YCQ 30.8304 41.5153 -0.69 1ycqA00 B=5 C=21 H=58 T=16 C=36 H=45 T=18 XENOPUS LAEVIS MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF HUMAN P53 -18.1 B 11 A All alpha proteins d1ycqa_ 58 45 -1.98 P56273 E3 ubiquitin-protein ligase Mdm2 MDM2_XENLA MNLTSTTNCLENNHISTSDQEKLVQPTPLLLSLLKSAGAQKETFTMKEVIYHLGQYIMAKQLYDEKQQHIVHCSNDPLGELFGVQEFSVKEPRRLYAMISRNLVSANVKESSEDIFGNVCCFPDKQSSQKEKLQELPDKLIAPASDSKPCNLSQRKSSNETEEISSVDHPAEQQRKRHKSDSFSLTFDESLSWWVISGLRCDRNSSESTDSSSNSDPERHSTNDNSEHDSDQFSVEFEVESVCSDDYSPSGDEHGVSEEEEINDEVYQVTIYETEESETDSFDVDTEISEADYWKCPECGEVNPPLPSYCPRCWTVRKDWLPEQRRKEPPPSKRKLLEIEEDEGFDVPDCKKSKLTSSQDTNVDKKEAENIQNSESQETEDCSQPSTSGSIASCSQEVTKEDSSKESMESSLPLTSIDPCVICQTRPKNGCIVHGRTGHLMACYTCAKKLKKRNKPCPVCREPIQMIVLTYFS 27647 3DAB 45.815 64.5025 -1.09 B=6 C=28 H=50 T=17 C=36 H=45 T=18 Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain -16.93 D 11 C 50 45 -0.73 O15151 Protein Mdm4 MDM4_HUMAN MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA 27647 3G03 37.3041 50.4746 -1.84 B=5 C=10 H=60 T=25 C=27 H=55 T=18 Structure of human MDM2 in complex with high affinity peptide -19.5 B 11 ACD 60 55 -1.29 Q00987 E3 ubiquitin-protein ligase Mdm2 MDM2_HUMAN MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP 27647 3DAC 13.3874 19.6869 -1.22 B=5 C=19 H=52 T=24 C=42 H=42 T=17 Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain -18.71 P 12 M 52 42 -1.26 Q7ZUW7 Protein Mdm4 MDM4_DANRE MTSLASSSQLPGSCRTLPGEGTQVHPRAPLLQILKVAGAQEEVFTLKEVMHYLGQYIMMKQLYDKQRQHIVHCHDDPLGELLEVGSFSVKNPSPVYEMLKRNLVILNNSDAAKNLSVGKDSNESPSEDPGQVSSGSINSAQPLIAGSSSTGTTQSCSQRRPRDPDEDSSDGLPRSACKRPKLDVTLEEWDLSGLPWWFLGNLRSNYTRRSNGSTDIHTNQLSPGQDEDTAIVSDTTDDLWFLNEAESEQVSVEIKEAVLEQGSDGESPHEDEDTGKDSKDDGKMQEEQEEDSQCLSDDTDTEISTQDAWQCSECRKFNTPLQRYCMRCWALRKDWYKDCPRLVHSISVPDIPACSSRPERDEDEEEEDDDGIDMPDCLRTVSDPVVLPSHRVSRNIPSSSASSSKGKGPSQIHHHFQETSEGDSQDTLDMETEYQPEALLEPCKLCRVRPRNGNIIHGRTAHLITCFPCARKLHKFHAPCPGCGQVIQKVIKTFIA 27647 3FDO 23.9556 20.2151 -1.6 C=20 E=15 H=50 T=15 C=33 H=50 T=17 Structure of human MDMX in complex with high affinity peptide -20.86 B 12 A 65 50 -1.12 O15151 Protein Mdm4 MDM4_HUMAN MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA 27647 1T4F 27.6882 48.1542 -1.38 1t4fM00 C=10 E=20 H=65 T=5 C=22 H=56 T=22 Structure of human MDM2 in complex with an optimized p53 peptide -18.31 P 9 M All alpha proteins d1t4fm1 85 56 -1.51 Q00987 E3 ubiquitin-protein ligase Mdm2 MDM2_HUMAN MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP 27647 2Z5S 49.9349 57.8216 0 2z5sN00 B=5 C=20 E=5 H=50 T=20 C=30 H=50 T=20 Molecular basis for the inhibition of p53 by Mdmx 0 R 10 O 55 50 0 Q7ZUW7 Protein Mdm4 MDM4_DANRE MTSLASSSQLPGSCRTLPGEGTQVHPRAPLLQILKVAGAQEEVFTLKEVMHYLGQYIMMKQLYDKQRQHIVHCHDDPLGELLEVGSFSVKNPSPVYEMLKRNLVILNNSDAAKNLSVGKDSNESPSEDPGQVSSGSINSAQPLIAGSSSTGTTQSCSQRRPRDPDEDSSDGLPRSACKRPKLDVTLEEWDLSGLPWWFLGNLRSNYTRRSNGSTDIHTNQLSPGQDEDTAIVSDTTDDLWFLNEAESEQVSVEIKEAVLEQGSDGESPHEDEDTGKDSKDDGKMQEEQEEDSQCLSDDTDTEISTQDAWQCSECRKFNTPLQRYCMRCWALRKDWYKDCPRLVHSISVPDIPACSSRPERDEDEEEEDDDGIDMPDCLRTVSDPVVLPSHRVSRNIPSSSASSSKGKGPSQIHHHFQETSEGDSQDTLDMETEYQPEALLEPCKLCRVRPRNGNIIHGRTAHLITCFPCARKLHKFHAPCPGCGQVIQKVIKTFIA