25482 1C5Y 36.622 49.5588 -2.73 1c5yB01 B=5 C=59 E=9 G=5 S=5 T=18 C=78 T=22 STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR -10.78 A 9 B 9 0 -1.82 25482 1GJC 38.2603 47.7387 -2.76 1gjcB01 B=5 C=57 E=10 G=5 S=5 T=19 C=78 T=22 ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS -11.14 A 9 B 10 0 -1.23 25482 1GJ7 34.498 44.6121 -3.34 1gj7B01 B=5 C=57 E=10 G=5 S=5 T=19 C=80 T=20 ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS -12.72 A 10 B 10 0 -2.32 25482 1O5C 30.4677 40.6709 -2.97 1o5cB01 B=5 C=52 E=10 G=5 S=10 T=19 C=78 T=22 Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA) -10.02 A 9 B 10 0 -1.99 25482 1C5Z 35.695 47.3493 -2.66 1c5zB01 B=5 C=59 E=5 G=5 S=9 T=18 C=78 T=22 STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR -12.34 A 9 B 5 0 -2.91 25482 1GJD 35.1215 46.8557 -3.09 1gjdB01 B=5 C=48 E=10 G=14 S=5 T=19 C=54 G=31 T=15 ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS -13.46 A 13 B 10 0 -1.95 25482 1GJ8 38.2627 51.6702 -3.3 1gj8B01 B=6 C=50 E=6 G=17 T=22 C=54 G=31 T=15 ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS -15.7 A 13 B 6 0 -1.86 25482 1GI7 30.6753 42.5402 -3.06 1gi7B01 B=6 C=61 E=6 G=6 T=22 C=78 T=22 A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE -11.15 A 9 B 6 0 -1.89 25482 1GJ9 34.6872 47.1693 -4.96 1gj9B01 B=5 C=55 E=9 G=5 S=9 T=18 C=80 T=20 ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS -13.99 A 10 B 9 0 -3.86 25482 1GI8 36.2048 48.5633 -3.29 1gi8B01 B=6 C=61 E=6 G=6 T=22 C=78 T=22 A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE -12.26 A 9 B 6 0 -1.86 25482 1O3P 29.0051 37.8699 -2.6 1o3pB01 B=6 C=61 E=6 G=6 T=22 C=75 T=25 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors -10.28 A 8 B 6 0 -1.24 25482 1C5W 42.4345 57.8523 -2.82 1c5wB01 B=5 C=62 E=5 G=5 S=5 T=19 C=78 T=22 STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR -11.03 A 9 B 5 0 -1.79 25482 1GJA 35.2653 48.587 -3.29 1gjaB01 B=5 C=53 E=5 G=16 S=5 T=16 C=54 G=31 T=15 ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS -14.27 A 13 B 5 0 -2.13 25482 1GI9 32.9563 47.6881 -3.4 1gi9B01 B=6 C=61 E=6 G=6 T=22 C=78 T=22 A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE -12.72 A 9 B 6 0 -1.86 25482 1O5A 35.9301 46.8986 -3.14 1o5aB01 B=5 C=57 E=5 G=5 S=10 T=19 C=78 T=22 Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA) -9.56 A 9 B 5 0 -2 25482 1C5X 38.8298 54.4131 -2.86 1c5xB01 B=5 C=57 E=5 G=5 S=10 T=19 C=78 T=22 STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR -10.63 A 9 B 5 0 -1.37 25482 1GJB 37.8049 43.5508 -2.71 1gjbB01 B=6 C=59 E=12 G=6 T=18 C=75 T=25 ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS -12.6 A 8 B 12 0 -2.8 25482 1O5B 40.5619 55.2222 -2.71 1o5bB01 B=6 C=59 E=6 G=6 T=24 C=75 T=25 Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA) -10.83 A 8 B 6 0 -1.73